News

Publications

Mucus-Penetrating Nanoparticles Made with “Mucoadhesive” Poly(Vinyl Alcohol)
Alexey Popov, Elizabeth Enlow, James Bourassa, Hongming Chen
Nanomedicine: Nanotechnology, Biology, and Medicine 2016, 12(7), 1863-1871

Enhanced Pulmonary Delivery of Fluticasone Propionate in Rodents by Mucus-Penetrating Nanoparticles
Alexey Popov, Lisa Schopf, James Bourassa, Hongming Chen
Int. J. Pharm. 2016, 502(1-2), 188-197

Sustained Pulmonary Delivery of a Water-Soluble Antibiotic Without Encapsulating Carriers
Winston Ong, Pawel Nowak, Yen Cu, Lisa Schopf, James Bourassa, Elizabeth Enlow, Samuel M. Moskowitz and Hongming Chen
Pharm. Res. 2016, 33, 563-572

Topical Ocular Drug Delivery to the Back of the Eye by Mucus-Penetrating Particles
Lisa R. Schopf, Alexey M. Popov, Elizabeth M. Enlow, James L. Bourassa, Winston Z. Ong, Pawel Nowak, and Hongming Chen
Trans. Vis. Sci. Tech. 2015, 4(3), 11

Topical Delivery of a Novel Receptor Tyrosine Kinase Inhibitor (RTKi) via Mucus-Penetrating Particles
Lisa Schopf, Elizabeth Enlow, Pawel Nowak, Winston Ong, James Bourassa, Kim Brazzell, Hongming Chen
Poster presented at the ARVO 2015 Annual Meeting

Mucus-Penetrating Particles of a Novel Receptor Tyrosine Kinase Inhibitor
Elizabeth Enlow, Pawel Nowak, Winston Ong, Jim Bourassa, Kim Brazzell, Hongming Chen, and Lisa Schopf
Poster presented at the World Congress on Angiogenesis 2015 Meeting

Mucus-Penetrating Antibiotic Prodrug Nanosuspension for Treatment of Infections at the Mucosal Surface
Yen Cu, Pawel Novak, Winston Ong, Jim Bourassa, Alexey Popov, and Hongming Chen
Poster presented at the AAPS 2014 Annual Meeting

Enhanced Topical Delivery of a Novel Loteprednol Etabonate Ophthalmic Formulation 
Lisa Schopf, Elizabeth Enlow, Alexey Popov, Jim Bourassa, and Hongming Chen.
Poster presented at the ARVO 2014 Annual Meeting

Evaluation of the Pharmacokinetic Profile of a Novel Ophthalmic Formulation of Loteprednol Etabonate
Kim Brazzell, Lisa Schopf, Elizabeth Enlow, Alexey Popov, Jim Bourassa, and Hongming Chen
Poster presented at the American Society of Cataract and Refractive Surgery 2014 Annual Meeting

Ocular Pharmacokinetics of a Novel Loteprednol Etabonate 0.4% Ophthalmic Formulation
Lisa Schopf, Elizabeth Enlow, Alexey Popov, James Bourassa, and Hongming Chen
Ophthalmol. Ther. 2014, 3(1-2), 63-72

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier
J. S. Suk, A. J. Kim, K. Trehan, C. S. Schneider, L. Cebotaru, O. M. Woodward, N. J. Boylan, M. P. Boyle, S. K. Lai, W. B. Guggino, J. Hanes
J. Control. Release. 2014, 28;178:8-17

Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus
L. M. Ensign, B. C. Tang, Y. Y. Wang, T. A. Tse, T. Hoen, R. Cone, and J. Hanes
Sci. Transl. Med. 2012, 4, 138ra79.

Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus
M. Yang, S. K. Lai, Y.Y. Wang, W. Zhong, C. Happe, M. Zhang, J. Fu, and J. Hanes
Angew. Chem. Int. Ed. 2011, 50, 2597-2600.

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
S. K. Lai, Y. Y. Wang, and J. Hanes
Adv. Drug Del. Rev. 2009, 61, 158-171.

Altering mucus rheology to “solidify” human mucus at the nanoscale
S. K. Lai, Y. Y. Wang, R.Cone, D. Wirtz, and J. Hanes
PLoS ONE 2009, 4, e4294.

The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles
J. S. Suk, S. K. Lai, Y. Y. Wang, L. M. Ensign, P. L. Zeitlin, M. P. Boyle, and J. Hanes
Biomaterials 2009, 30, 2591-2597

Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
S. K. Lai, D. E. O’Hanlon, S. Harrold, S. T. Man, Y. Y. Wang, R. Cone, and J. Hanes
PNAS 2007, 104, 1482-1487.